Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Osteocytes comprise the overwhelming majority of cells in bone and are its only true
“permanent” resident cell population. In recent years, conceptual and technological …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

A major challenge for successful cultured meat production is the requirement for large
quantities of skeletal muscle satellite cells (MuSCs). Commercial microcarriers (MCs), such …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes
through signaling pathways that affect cellular proliferation, migration, mechanotransduction …

Adhesion between cardiac myocytes is essential for the heart to function as an
electromechanical syncytium. Although cell-matrix and cell–cell adhesions reorganize …

Extensive research over the past decades has identified integrins to be the primary
transmembrane receptors that enable cells to respond to external mechanical cues. We …

Atherosclerotic plaque localization correlates with regions of disturbed flow in which
endothelial cells (ECs) align poorly, whereas sustained laminar flow correlates with cell …