Uveal melanoma is the most common primary malignant tumor of the eye in adults,
predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet …

Multiplex Ligation-dependent Probe Amplification (MLPA) assay is a recently developed
technique able to evidence variations in the copy number of several human genes. Due to …

Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical
or radiation treatment of primary tumours,~ 50% of patients progress to metastatic disease …

Purpose: Metastasis from uveal melanoma occurs almost exclusively with tumors showing
chromosome 3 loss. We used multiplex ligation-dependent probe amplification (MLPA) to …

Uveal melanoma (UM) is the most common primary intraocular malignancy affecting adults.
Despite successful local treatment of the primary tumour, metastatic disease develops in up …

Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …

Purpose.: Somatic mutations in GNAQ, GNA11, SF3B1, EIF1AX, and BAP1 have been
identified in uveal melanoma (UM). The aim of this study was to determine whether …

Like other cancers, uveal melanomas (UM) are characterised by an uncontrolled, clonal,
cellular proliferation, occurring as a result of numerous genetic, and epigenetic aberrations …

Uveal melanoma, which arises from melanocytes residing in the stroma, is the most common
primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will …