Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma

A Zaritsky, AR Jamieson, ES Welf, A Nevarez, J Cillay… - Cell systems, 2021 - cell.com
Deep learning has emerged as the technique of choice for identifying hidden patterns in cell
imaging data but is often criticized as" black box." Here, we employ a generative neural …

Five priority areas for improving medications development for alcohol use disorder and promoting their routine use in clinical practice.

RZ Litten, DE Falk, ML Ryan, J Fertig… - Alcoholism: Clinical and …, 2020 - psycnet.apa.org
The article discusses about the priority areas for improving medications development for
alcohol use disorder and promoting their routine use in clinical practice. During the past 25 …

Computational approaches for high‐throughput single‐cell data analysis

H Todorov, Y Saeys - The FEBS journal, 2019 - Wiley Online Library
During the past decade, the number of novel technologies to interrogate biological systems
at the single‐cell level has skyrocketed. Numerous approaches for measuring the proteome …

Predicting chemical-induced liver toxicity using high-content imaging phenotypes and chemical descriptors: a random forest approach

S Chavan, N Scherbak, M Engwall… - Chemical Research in …, 2020 - ACS Publications
Hepatotoxicity is a major reason for the withdrawal or discontinuation of drugs from clinical
trials. Thus, better tools are needed to filter potential hepatotoxic drugs early in drug …

New software for automated cilia detection in cells (ACDC)

MC Lauring, T Zhu, W Luo, W Wu, F Yu, D Toomre - Cilia, 2019 - Springer
Background Primary cilia frequency and length are key metrics in studies of ciliogenesis and
ciliopathies. Typically, quantitative cilia analysis is done manually, which is very time …

Quantitative cell imaging approaches to metastatic state profiling

AJ Nevarez, N Hao - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Genetic heterogeneity of metastatic dissemination has proven challenging to identify
exploitable markers of metastasis; this bottom-up approach has caused a stalemate …

Interpretable deep learning of label-free live cell images uncovers functional hallmarks of highly-metastatic melanoma

A Zaritsky, AR Jamieson, ES Welf, A Nevarez, J Cillay… - BioRxiv, 2020 - biorxiv.org
Deep convolutional neural networks have emerged as a powerful technique to identify
hidden patterns in complex cell imaging data. However, these machine learning techniques …

Novel image analysis tool for rapid screening of cell morphology in preclinical animal models of disease

M Guignet, M Schmuck, DJ Harvey, D Nguyen, D Bruun… - Heliyon, 2023 - cell.com
The field of cell biology has seen major advances in both cellular imaging modalities and
the development of automated image analysis platforms that increase rigor, reproducibility …

Новая компьютерная программа автоматизированного анализа движения цилиарного эпителия респираторного тракта для диагностики первичной …

ТА Киян, CА Смирнихина, АГ Демченко… - …, 2024 - journal.pulmonology.ru
Аннотация Первичная цилиарная дискинезия (ПЦД)–редкое наследственное
заболевание из группы цилиопатий, при котором нарушены структура и подвижность …