The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs),
which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor …

Thyroid hormones (TH) are endocrine messengers essential for normal development and
function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely …

Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …

Ever since the discovery of thyroid hormone deficiency as the primary cause of cretinism in
the second half of the 19th century, the crucial role of thyroid hormone (TH) signaling in …

We gathered available RNA-seq and ChIP-seq data in a single database to better
characterize the target genes of thyroid hormone receptors in several cell types. This …

The fundamental principle in regulatory toxicology is that all chemicals are toxic and that the
severity of effect is proportional to the exposure level. An ancillary assumption is that there …

Background Thyroid hormone controls a number of developmental and physiological
processes in the brain by directly acting on gene expression. Transcriptome analyses in …

Thyroid hormones (THs) regulate gene expression by binding to nuclear TH receptors (TRs)
in the cell. THs are indispensable for brain development. However, we have little knowledge …

Astrocytes, initially described as merely support cells, are now known as a heterogeneous
population of cells actively involved in a variety of biological functions such as: neuronal …