[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
Synthetic biology strategies for microbial biosynthesis of plant natural products
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
Charting the evolution of chemoenzymatic strategies in the syntheses of complex natural products
CN Stout, NM Wasfy, F Chen… - Journal of the American …, 2023 - ACS Publications
Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …
[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …
CRISPR-Cpf1-assisted multiplex genome editing and transcriptional repression in Streptomyces
L Li, K Wei, G Zheng, X Liu, S Chen… - Applied and …, 2018 - Am Soc Microbiol
Streptomyces has a strong capability for producing a large number of bioactive natural
products and remains invaluable as a source for the discovery of novel drug leads. Although …
products and remains invaluable as a source for the discovery of novel drug leads. Although …
Recent Advances in Silent Gene Cluster Activation in Streptomyces
Z Liu, Y Zhao, C Huang, Y Luo - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Natural products (NPs) are critical sources of drug molecules for decades. About two-thirds
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …
Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering
ON Sekurova, O Schneider… - Microbial biotechnology, 2019 - Wiley Online Library
For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …
some of which were eventually developed into drugs to treat infections, cancer and immune …
Promoter-Library-Based Pathway Optimization for Efficient (2S)-Naringenin Production from p-Coumaric Acid in Saccharomyces cerevisiae
Pathway optimization plays an important role in fine-tuning metabolic pathways. In most
conditions, more than three genes are involved in the biosynthesis pathway of a specific …
conditions, more than three genes are involved in the biosynthesis pathway of a specific …
Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential
S Agrawal, D Acharya, A Adholeya… - Frontiers in …, 2017 - frontiersin.org
Marine environments are largely unexplored and can be a source of new molecules for the
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Covering: 2000 to 2016 The labor-intensive process of microbial natural product discovery is
contingent upon identifying discrete secondary metabolites of interest within complex …
contingent upon identifying discrete secondary metabolites of interest within complex …