[HTML][HTML] Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease

P Pleskač, CA Fargeas, R Veselska, D Corbeil… - Cellular & Molecular …, 2024 - Springer
Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …

Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression

L Zhou, HO Ken, TL Wong, Z Zhang, CH Chan… - Gut, 2022 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which
contributes to therapeutic resistance and tumour recurrence. We previously identified …

[HTML][HTML] Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7

H Lee, DM Yu, MS Bahn, YJ Kwon, MJ Um… - … & Molecular Medicine, 2022 - nature.com
Abstract Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor
cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is …

[HTML][HTML] GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice

L Li, Y He, K Liu, L Liu, S Shan, H Liu, J Ren… - Cell Death & …, 2024 - nature.com
As an alternative pathway for liver regeneration, liver progenitor cells and their derived
ductular reaction cells increase during the progression of many chronic liver diseases …

TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia

C Short, A Zhong, J Xu, E Mahdi, A Glazier… - Hepatology, 2023 - journals.lww.com
TWEAK/FN14 promotes profibrogenic pathway activation in Prom... : Hepatology TWEAK/FN14
promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor …

Potential biomarkers in the fibrosis progression of nonalcoholic steatohepatitis (NASH)

Z Wang, Z Zhao, Y Xia, Z Cai, C Wang, Y Shen… - Journal of …, 2022 - Springer
Purpose Fibrosis is the only histological feature reflecting the severity and prognosis of
nonalcoholic steatohepatitis (NASH). We aim to explore novel genes associated with fibrosis …

CD133‐Src‐TAZ signaling stimulates ductal fibrosis following DDC diet‐induced liver injury

HT Oh, W Heo, GD Yoo, KM Kim… - Journal of Cellular …, 2022 - Wiley Online Library
Chronic liver injury follows inflammation and liver fibrosis; however, the molecular
mechanism underlying fibrosis has not been fully elucidated. In this study, the role of ductal …

[HTML][HTML] Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following cholestatic liver injury

A Zhong, C Short, J Xu, GE Fernandez… - Hepatology …, 2023 - journals.lww.com
Prominin-1 promotes restitution of the murine extrahepatic b... : Hepatology Communications
Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following …

Keratin 19 (Krt19) is a novel marker gene for epicardial cells

J Xu, Y Deng, G Li - Frontiers in Genetics, 2024 - frontiersin.org
Epicardial cells regulate heart growth by secreting numerous growth factors and undergoing
lineage specification into other cardiac lineages. However, the lack of specific marker genes …

Upregulation of cadherin-11 contributes to cholestatic liver fibrosis

B Wu, X Tian, W Wang, J Zhu, Y Lu, J Du… - Pediatric …, 2022 - mednexus.org
Importance: Cadherin-11 (CDH11), a cell-to-cell adhesion molecule, is implicated in the
fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease …