[HTML][HTML] Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
P Pleskač, CA Fargeas, R Veselska, D Corbeil… - Cellular & Molecular …, 2024 - Springer
Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …
associated with highly curved and prominent membrane structures. It is widely recognized …
Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression
Objective Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which
contributes to therapeutic resistance and tumour recurrence. We previously identified …
contributes to therapeutic resistance and tumour recurrence. We previously identified …
[HTML][HTML] Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7
H Lee, DM Yu, MS Bahn, YJ Kwon, MJ Um… - … & Molecular Medicine, 2022 - nature.com
Abstract Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor
cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is …
cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is …
[HTML][HTML] GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice
L Li, Y He, K Liu, L Liu, S Shan, H Liu, J Ren… - Cell Death & …, 2024 - nature.com
As an alternative pathway for liver regeneration, liver progenitor cells and their derived
ductular reaction cells increase during the progression of many chronic liver diseases …
ductular reaction cells increase during the progression of many chronic liver diseases …
TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia
C Short, A Zhong, J Xu, E Mahdi, A Glazier… - Hepatology, 2023 - journals.lww.com
TWEAK/FN14 promotes profibrogenic pathway activation in Prom... : Hepatology TWEAK/FN14
promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor …
promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor …
Potential biomarkers in the fibrosis progression of nonalcoholic steatohepatitis (NASH)
Z Wang, Z Zhao, Y Xia, Z Cai, C Wang, Y Shen… - Journal of …, 2022 - Springer
Purpose Fibrosis is the only histological feature reflecting the severity and prognosis of
nonalcoholic steatohepatitis (NASH). We aim to explore novel genes associated with fibrosis …
nonalcoholic steatohepatitis (NASH). We aim to explore novel genes associated with fibrosis …
CD133‐Src‐TAZ signaling stimulates ductal fibrosis following DDC diet‐induced liver injury
HT Oh, W Heo, GD Yoo, KM Kim… - Journal of Cellular …, 2022 - Wiley Online Library
Chronic liver injury follows inflammation and liver fibrosis; however, the molecular
mechanism underlying fibrosis has not been fully elucidated. In this study, the role of ductal …
mechanism underlying fibrosis has not been fully elucidated. In this study, the role of ductal …
[HTML][HTML] Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following cholestatic liver injury
A Zhong, C Short, J Xu, GE Fernandez… - Hepatology …, 2023 - journals.lww.com
Prominin-1 promotes restitution of the murine extrahepatic b... : Hepatology Communications
Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following …
Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following …
Keratin 19 (Krt19) is a novel marker gene for epicardial cells
Epicardial cells regulate heart growth by secreting numerous growth factors and undergoing
lineage specification into other cardiac lineages. However, the lack of specific marker genes …
lineage specification into other cardiac lineages. However, the lack of specific marker genes …
Upregulation of cadherin-11 contributes to cholestatic liver fibrosis
B Wu, X Tian, W Wang, J Zhu, Y Lu, J Du… - Pediatric …, 2022 - mednexus.org
Importance: Cadherin-11 (CDH11), a cell-to-cell adhesion molecule, is implicated in the
fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease …
fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease …