Metastatic disease is responsible for approximately 90% of cancer deaths. For successful
dissemination and metastasis, cancer cells must evade detection and destruction by the …

Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and
cell metabolism. Mitochondria contain their own circular genome encoding selected …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/
inflammatory diseases and cancers. Here, we report that exosomes can deliver anti …

Mesenchymal stromal cells (MSCs) are explored as a novel treatment for a variety of
medical conditions. Their fate after infusion is unclear, and long-term safety regarding …

Mechanisms behind how the immune system signals to the brain in response to systemic
inflammation are not fully understood. Transgenic mice expressing Cre recombinase …

Mitochondria are vital organelles in cells, regulating energy metabolism and apoptosis.
Mitochondrial transcellular transfer plays a crucial role during physiological and pathological …

Fusion of macrophages leads to the formation of osteoclasts in bone and of multinucleated
giant cells in granulomas. The precise function of granuloma-associated multinucleates …

Simple Summary In cancer, disseminated neoplastic cells circulating in blood are a source
of tumor DNA, RNA, and protein, which can be harnessed to diagnose, monitor, and better …

There is a steadily growing interest in the use of mitochondria as therapeutic agents. The
use of mitochondria derived from mesenchymal stem/stromal cells (MSCs) for therapeutic …