In recent years, spiro compounds have attracted significant interest in medicinal chemistry
due to their numerous biological activities attributed primarily to their versatility and structural …

We designed and synthesized a series of pyridine spiro derivatives and evaluated their
insecticidal and antiviral activities. Some compounds exhibited good insecticidal and …

A novel synthesis of 2‐hydroxy‐N′‐(2‐oxoindolin‐3‐ylidene) benzohydrazide derivatives
was synthesized by the condensation of 2‐hydroxybenzohydrazide with substituted isatins …

A series of spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles hybrid
compounds were prepared in good yields by regioselective, three-component, 1, 3-dipolar …

Dibenzoazepine, dibenzoxazepine and dibenzothiazepine scaffolds are an important class
of N‐heterocycles that possess multiple biological activities. Due to the widespread …

Heterocyclic compounds have been of great interest in the synthesis of many
pharmaceutical properties increasing their biological significance such as anesthesia …

The three-component cascade reaction of (E)-3-arylidene-1-methyl-pyrrolidine-2, 5-diones,
L-proline and isatin have been well established. It forms a new series of spiropyrrolizidine …

The selective functionalization of ubiquitous C (sp3)–H bonds for constructing complex
molecules is a highly sought-after method in academia as well as the chemical industry. In …

Background: Tuberculosis (TB) is the one which remains the world's greatest public health
challenges. Worldwide resurgence of TB is due to two major problems: the AIDS epidemic …

A series of 1, 4-thiazepin-5 (4 H)-one derivatives were synthesized via a transition metal-free
one-pot Smiles rearrangement process at room temperature. Regioselective seven …