The glenohumeral joint is a complex anatomic structure commonly affected by injury such as
tendinopathy and rotator cuff tears. This review presents an up-to-date overview of research …

As the primary producer of extracellular matrix (ECM) proteins in skeletal muscle, fibroblasts
play an important role providing structural support to muscle. Skeletal muscle ECM is vital for …

Background rotator cuff muscle atrophy, fibrosis and fatty infiltration are common
complications after large and massive rotator cuff tears. Currently, there are no effective …

In the musculoskeletal system, the myotendinous junction (MTJ) is optimally designed from
the aspect of force transmission generated from a muscle through a tendon onto the bone to …

Background: Massive rotator cuff tears (RCTs) begin as primary tendon injuries and cause a
myriad of changes in the muscle, including atrophy, fatty infiltration (FI), and fibrosis …

Background: Chronic rotator cuff tears present a clinical challenge, often with poor outcomes
after surgical repair. Degenerative changes to the muscle, tendon, and bone are thought to …

Background Chronic massive rotator cuff tears heal poorly and often retear. This study
investigated the effect of adipose-derived stem cells (ADSCs) and transforming growth factor …

The high prevalence of rotator cuff tears poses challenges to individual patients and the
healthcare system at large. This orthopedic injury is complicated further by high rates of …

Tissue extracellular matrix (ECM) provides structural support and creates unique
environments for resident cells (Bateman JF, Boot-Handford RP, Lamandé SR. Nat Rev …

Tissue engineering aims to bring together biomaterials, cells, and signaling molecules
within properly designed microenvironments in order to create viable treatment options for …