Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …

Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …

Antimicrobial resistance (AMR) is a clear and present danger to patients in any intensive
care unit (ICU) around the world. Whereas AMR may affect any patient in the hospital …

Background Critically ill patients undergo extensive physiological alterations that will have
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …

Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

Background The broad‐spectrum triazole isavuconazole is used for the treatment of invasive
aspergillosis and mucormycosis. Data regarding human plasma concentrations in clinical …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …