Tackling the emerging threat of antifungal resistance to human health
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
Bloodstream infections in critically ill patients: an expert statement
Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …
signs of infection and may be either secondary to a documented source or primary—that is …
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial
TMJ Ewoldt, A Abdulla, WJR Rietdijk, AE Muller… - Intensive Care …, 2022 - Springer
Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …
Rationalizing antimicrobial therapy in the ICU: a narrative review
The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …
[HTML][HTML] Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives
F de Velde, JW Mouton, BCM de Winter… - Pharmacological …, 2018 - Elsevier
Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …
a growing need to optimize the use of old and new antibiotics. Modelling of the …
Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM …
Antimicrobial resistance (AMR) is a clear and present danger to patients in any intensive
care unit (ICU) around the world. Whereas AMR may affect any patient in the hospital …
care unit (ICU) around the world. Whereas AMR may affect any patient in the hospital …
The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre …
A Abdulla, TMJ Ewoldt, NGM Hunfeld, AE Muller… - BMC infectious …, 2020 - Springer
Background Critically ill patients undergo extensive physiological alterations that will have
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …
impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet …
Model‐informed drug development for anti‐infectives: state of the art and future
CR Rayner, PF Smith, D Andes… - Clinical …, 2021 - Wiley Online Library
Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …
diseases. This review describes foundational principles of translational anti‐infective …
Isavuconazole therapeutic drug monitoring in critically ill ICU patients: a monocentric retrospective analysis
R Höhl, R Bertram, M Kinzig, GS Haarmeyer… - Mycoses, 2022 - Wiley Online Library
Background The broad‐spectrum triazole isavuconazole is used for the treatment of invasive
aspergillosis and mucormycosis. Data regarding human plasma concentrations in clinical …
aspergillosis and mucormycosis. Data regarding human plasma concentrations in clinical …
Pharmacokinetics and target attainment of antibiotics in critically ill children: a systematic review of current literature
SJF Hartman, RJ Brüggemann, L Orriëns, N Dia… - Clinical …, 2020 - Springer
Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …