Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …

As reviewed in this paper, meningococcal disease epidemiology varies substantially by
geographic area and time. The disease can occur as sporadic cases, outbreaks, and large …

The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Gram-negative bacteria release vesicular structures from their outer membrane, so called
outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal …

The epidemiology of invasive meningococcal disease continues to change rapidly, even in
the three years since the first Meningococcal Exchange Meeting in 2008. Control of disease …

Meningococcal outer membrane proteins have been used for over 20 years in more than 80
million doses; either as carrier protein in a Haemophilus influenzae type b (Hib) …

The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with
the classical hypothesis-driven laboratory-based analysis of microbes to identify …

Abstract Background In January 2005, a quadrivalent (serogroups A, C, Y, and W-135)
meningococcal conjugate vaccine was licensed for use in adolescents. This report …

Background Effective glycoconjugate vaccines against Neisseria meningitidis serogroups A,
C, W-135, and Y have been developed, but serogroup B remains a major cause of severe …

The utility of wild-type outer membrane vesicle (wtOMV) vaccines against serogroup B
(MenB) meningococcal disease has been explored since the 1970s. Public health …