Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology and target identification and in the evaluation of novel …

Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes
mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death …

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Macrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases.
In fact, during these diseases, activated macrophages may play a critical role, promoting the …

Dystrophin-deficient muscles experience large reductions in expression of nitric oxide
synthase (NOS), which suggests that NO deficiency may influence the dystrophic pathology …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Type 1 diabetes results from the destruction of insulin-producing pancreatic β cells by a β
cell-specific autoimmune process. β Cell autoantigens, macrophages, dendritic cells, B …