Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

[HTML][HTML] Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity

EC Rosenberg, S Chamberland, M Bazelot, ER Nebet… - Neuron, 2023 - cell.com
Summary Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …

Inhibitory effects of cannabidiol on voltage-dependent sodium currents

MR Ghovanloo, NG Shuart, J Mezeyova… - Journal of Biological …, 2018 - ASBMB
Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment

M Premoli, F Aria, SA Bonini, G Maccarinelli… - Life sciences, 2019 - Elsevier
The pharmacological research on the Cannabis sativa-derived compounds has never
terminated. Among the phytocannabinoids without psychotropic effects, the prevalent one in …

Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings

S Elsaid, S Kloiber, B Le Foll - Progress in molecular biology and …, 2019 - Elsevier
Cannabis sativa (cannabis) is one of the oldest plants cultivated by men. Cannabidiol (CBD)
is the major non-psychomimetic compound derived from cannabis. It has been proposed to …

Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?

LE Filipiuc, DC Ababei, T Alexa-Stratulat, CV Pricope… - Pharmaceutics, 2021 - mdpi.com
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …

Aberrant excitatory–inhibitory synaptic mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer's disease

AL Petrache, A Rajulawalla, A Shi, A Wetzel… - Cerebral …, 2019 - academic.oup.com
Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …

Cannabidiol activates neuronal Kv7 channels

HXB Zhang, L Heckman, Z Niday, S Jo, A Fujita, J Shim… - Elife, 2022 - elifesciences.org
Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective
antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based …

Cannabidiol inhibits the skeletal muscle Nav1. 4 by blocking its pore and by altering membrane elasticity

MR Ghovanloo, K Choudhury, TS Bandaru… - Journal of General …, 2021 - rupress.org
Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis
sativa, which has been proposed to be therapeutic against many conditions, including …