Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
Cannabinoids and the expanded endocannabinoid system in neurological disorders
L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …
[HTML][HTML] Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
EC Rosenberg, S Chamberland, M Bazelot, ER Nebet… - Neuron, 2023 - cell.com
Summary Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
MR Ghovanloo, NG Shuart, J Mezeyova… - Journal of Biological …, 2018 - ASBMB
Cannabis sativa contains many related compounds known as phytocannabinoids. The main
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …
psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and …
Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment
M Premoli, F Aria, SA Bonini, G Maccarinelli… - Life sciences, 2019 - Elsevier
The pharmacological research on the Cannabis sativa-derived compounds has never
terminated. Among the phytocannabinoids without psychotropic effects, the prevalent one in …
terminated. Among the phytocannabinoids without psychotropic effects, the prevalent one in …
Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings
Cannabis sativa (cannabis) is one of the oldest plants cultivated by men. Cannabidiol (CBD)
is the major non-psychomimetic compound derived from cannabis. It has been proposed to …
is the major non-psychomimetic compound derived from cannabis. It has been proposed to …
Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …
chemotherapeutics, started from natural extracts which have been found to have effects in …
Aberrant excitatory–inhibitory synaptic mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer's disease
AL Petrache, A Rajulawalla, A Shi, A Wetzel… - Cerebral …, 2019 - academic.oup.com
Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …
Cannabidiol activates neuronal Kv7 channels
Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective
antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based …
antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based …
Cannabidiol inhibits the skeletal muscle Nav1. 4 by blocking its pore and by altering membrane elasticity
MR Ghovanloo, K Choudhury, TS Bandaru… - Journal of General …, 2021 - rupress.org
Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis
sativa, which has been proposed to be therapeutic against many conditions, including …
sativa, which has been proposed to be therapeutic against many conditions, including …