Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant (AMR) infections …

Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …

Controversy reigns as to how protein binding changes alter the time course of unbound drug
concentrations in patients. Given that the unbound concentration is responsible for drug …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill
patients is growing in popularity, although there are limited data describing the potential …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …