Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development

AJ van Wijnen, L Bagheri, AA Badreldin, AN Larson… - Bone, 2021 - Elsevier
Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

[HTML][HTML] Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription

Q Chen, H Wang, Z Li, F Li, L Liang, Y Zou, H Shen… - Journal of …, 2022 - Elsevier
Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with
high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in …

[HTML][HTML] Chromobox proteins in cancer: Multifaceted functions and strategies for modulation

J Wang, B Yang, X Zhang, S Liu… - International …, 2023 - spandidos-publications.com
Chromobox (CBX) proteins are important epigenetic regulatory proteins and are widely
involved in biological processes, such as embryonic development, the maintenance of stem …

[HTML][HTML] KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway

F Zeng, L Luo, D Li, J Guo, M Guo - Journal of Translational Medicine, 2021 - Springer
Abstract Background Bladder cancer (BCa) is a common malignancy characterized by high
heterogeneity, yet the current treatment modalities are limited. The aim of the present …

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

ER Verrier, G Ligat, L Heydmann, K Doernbrack… - Gut, 2023 - gut.bmj.com
Objectives Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and
hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently …

Long noncoding RNA MIR100HG knockdown attenuates hepatocellular carcinoma progression by regulating microRNA‐146b‐5p/Chromobox 6

F Li, X Sun, Q Liu, X Liu, J Zhang - … Research and Practice, 2021 - Wiley Online Library
Purpose. Hepatocellular carcinoma (HCC) accounts for approximately ninety percent of
primary liver cancer. This study attempted to investigate the effects of the long noncoding …

[HTML][HTML] An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and …

Y Hu, X Zhang, Q Li, Q Zhou, D Fang, Y Lu - Computational and Structural …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality. This study aimed
to build a prognostic signature for HCC patients based on immune-related genes (IRGs) and …

Hepatitis B virus x gene‐downregulated growth‐arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y‐box …

X Yu, Z Ye, L Hou, X Zhang, Z Liu, R Wu… - Journal of Cell …, 2022 - Wiley Online Library
The long noncoding RNA growth‐arrest specific 5 (GAS5) is a suppressor of many cancers.
However, the role and mechanism of action of GAS5 in hepatitis B virus (HBV)‐related …

[HTML][HTML] Comprehensive analysis of the prognosis for chromobox family in gastric cancer

K Lin, J Zhu, C Hu, F Bu, C Luo, X Zhu… - Journal of …, 2020 - ncbi.nlm.nih.gov
Background Chromobox (CBX) family proteins are a class of transcriptional repressors
involved in epigenetic regulation and developmental processes of various tumors, including …

[HTML][HTML] hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma

Y Liang, ZJ Yu, M Liu, HM Liu… - Molecular …, 2021 - spandidos-publications.com
Diffuse large B‑cell lymphoma (DLBCL) is the most common type of non‑Hodgkin lymphoma
worldwide. Several studies have indicated that Homo sapiens (hsa)‑microRNA (miR)‑429 …