Epigenetic control of gene regulation during development and disease: A view from the retina
Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …
Transcription factor abnormalities in B-ALL leukemogenesis and treatment
The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …
Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …
control neurogenesis and cell-fate specification in the developing central nervous system. In …
Context-specific transcription factor functions regulate epigenomic and transcriptional dynamics during cardiac reprogramming
Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage
conversion, thereby reprogramming a somatic cell's identity. To determine the molecular …
conversion, thereby reprogramming a somatic cell's identity. To determine the molecular …
SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers
Z Lu, W Mao, H Yang… - The Journal of …, 2022 - Am Soc Clin Investig
Poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in
the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells …
the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells …
Evolution of Osteocrin as an activity-regulated factor in the primate brain
Sensory stimuli drive the maturation and function of the mammalian nervous system in part
through the activation of gene expression networks that regulate synapse development and …
through the activation of gene expression networks that regulate synapse development and …
Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease
TJ Cherry, MG Yang, DA Harmin… - Proceedings of the …, 2020 - National Acad Sciences
The interplay of transcription factors and cis-regulatory elements (CREs) orchestrates the
dynamic and diverse genetic programs that assemble the human central nervous system …
dynamic and diverse genetic programs that assemble the human central nervous system …
Partitioning of gene expression among zebrafish photoreceptor subtypes
Vertebrate photoreceptors are categorized into two broad classes, rods and cones,
responsible for dim-and bright-light vision, respectively. While many molecular features that …
responsible for dim-and bright-light vision, respectively. While many molecular features that …
Functional and evolutionary diversification of Otx2 and Crx in vertebrate retinal photoreceptor and bipolar cell development
Otx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and
bind to the common DNA-binding consensus sequence, but these two proteins have distinct …
bind to the common DNA-binding consensus sequence, but these two proteins have distinct …
MEF2 (myocyte enhancer factor 2) is essential for endothelial homeostasis and the atheroprotective gene expression program
Objective: Atherosclerosis predominantly forms in regions of oscillatory shear stress while
regions of laminar shear stress are protected. This protection is partly through the …
regions of laminar shear stress are protected. This protection is partly through the …