Glioblastoma (GB) is a highly aggressive cancer of the central nervous system, occurring in
the brain or spinal cord. Many factors such as angiogenesis are associated with GB …

Background: To recognize the action of pharmacologically approved anticancer drugs in
biological systems, information regarding its pharmacokinetics, such as its transport within …

Traditional cancer treatments have posed numerous obstacles, including toxicity, multiple
drug resistance, and financial cost. On the contrary, bioactive phytochemicals used in …

Background Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against
different types of cancers. In the present study, we investigated the anti-cancer activities of …

Difficult drug targets are becoming the normal course of business in drug discovery,
sometimes due to large interacting surfaces or only small differences in selectivity regions …

Objectives Nowadays, one of the most common gastrointestinal cancers is colorectal cancer
(CRC). Chemotherapy is still one of the main methods to treat cancer. However, the currently …

Colorectal cancer (CRC) is the second most common cause of cancer mortality, with
approximately 1.9 million new cases and 0.9 million deaths globally in 2020. One of the …

In this work, a tumor-targeting liposome containing anti-nucleolin aptamer AS1411 (Apt-Lip-
GEF) was developed to deliver gefitinib (GEF) for the treatment of colon cancer. The …

Purpose In recent years, tumour immunotherapy has ushered in a new era of oncology
treatment. However, the use of immune checkpoint inhibitors (ICIs) in the treatment of CRC …

Sorafenib tosylate (SORt) is an oral multikinase inhibitor used for treatment of advanced
renal cell, liver, and thyroid cancers. In this study, this drug was synthesized and its …