The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims
suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of …

Defining the cellular electrophysiological mechanisms for ventricular tachyarrhythmias is
difficult, given the wide array of potential mechanisms, ranging from abnormal automaticity to …

Myocardial ischemia occurs when blood flow to the heart is reduced, preventing the heart
muscle from receiving enough oxygen required for survival. Several anatomical and …

Ischaemic heart disease is considered as the single most frequent cause of death, provoking
more than 7 000 000 deaths every year worldwide. A high percentage of patients …

Cardiac cellular Ca2+ transient (CaT) alternans and electrocardiographic T-wave alternans
(TWA) often develop in myocardial ischemia, but the mechanisms for this relationship have …

Acidosis has complex electrophysiological effects, which are associated with a high
recurrence of ventricular arrhythmias. Through multi-scale cardiac computer modeling, this …

Myocardial infarction results in scar tissue that cannot actively contribute to heart mechanical
function and frequently causes lethal arrhythmias. The healing response after infarction …

Structural barriers to wave propagation in cardiac tissue are associated with a decreased
threshold for repolarization alternans both experimentally and clinically. Using computer …

Background Dorsal root ganglion stimulation (DRGS) may serve as a novel
neuromodulation strategy to reduce cardiac sympathoexcitation and ventricular excitability …