Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine
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Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …

This review considers critically the evidence for the involvement of mediators of innate and
acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate …

▪ Abstract C reactive protein, the first innate immunity receptor identified, and serum amyloid
P component are classic short pentraxins produced in the liver. Long pentraxins, including …

Annotated genome sequences, can be used to reconstruct whole-cell metabolic networks,,,.
These metabolic networks can be modelled and analysed (computed) to study complex …

Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern
recognition molecule conserved in evolution which acts as a key component of humoral …

Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can
orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis …

Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic
multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum …

Tumor-associated macrophages (TAMs), the most abundant immunosuppressive cells in the
tumor microenvironment, originate from blood monocytes and exhibit an IL-10highIL-12low …