Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to
produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Encapsulation of injury with fibrosis is a highly evolved response of adult tissues. In liver, the
components of the process have been greatly clarified, leading to a coherent view of how …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

Background/Aims: The activation of hepatic stellate cells is a key initiating event in hepatic
fibrogenesis. Although TGFβ1 is a potent inducer of collagen α1 (I) expression in vitro and …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Liver fibrosis represents a significant health problem worldwide of which no acceptable
therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I …

The poly (C) binding proteins (PCBPs) are encoded at five dispersed loci in the mouse and
human genomes. These proteins, which can be divided into two groups, hnRNPs K/J and …