Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes
A Asai, A Miethke, JA Bezerra - Nature reviews Gastroenterology & …, 2015 - nature.com
Biliary atresia is a severe cholangiopathy of early infancy that destroys extrahepatic bile
ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists …
ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists …
Genetics in biliary atresia
M Girard, G Panasyuk - Current opinion in gastroenterology, 2019 - journals.lww.com
Despite decades since its description and decades of intensive researches, cause of biliary
atresia disease remains enigmatic. The inheritance of biliary atresia is not Mendelian …
atresia disease remains enigmatic. The inheritance of biliary atresia is not Mendelian …
Identification of a plant isoflavonoid that causes biliary atresia
K Lorent, W Gong, KA Koo… - Science translational …, 2015 - science.org
Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown
etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest …
etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest …
[HTML][HTML] A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1
Y Chen, MA Gilbert, CM Grochowski, D McEldrew… - PLoS …, 2018 - journals.plos.org
Biliary atresia (BA) is a rare pediatric cholangiopathy characterized by fibrosclerosing
obliteration of the extrahepatic bile ducts, leading to cholestasis, fibrosis, cirrhosis, and …
obliteration of the extrahepatic bile ducts, leading to cholestasis, fibrosis, cirrhosis, and …
[HTML][HTML] Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations
P Linsuwanon, J Puenpa, SW Huang, YF Wang… - Journal of biomedical …, 2014 - Springer
Abstract Background Human enterovirus 71 (EV71) is an important pathogen caused large
outbreaks in Asian-Pacific region with severe neurological complications and may lead to …
outbreaks in Asian-Pacific region with severe neurological complications and may lead to …
Common genetic variants regulating ADD3 gene expression alter biliary atresia risk
Background & Aims Biliary atresia (BA) is a rare and most severe cholestatic disease in
neonates, but the pathogenic mechanisms are unknown. Through a previous genome wide …
neonates, but the pathogenic mechanisms are unknown. Through a previous genome wide …
Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia
EA Tsai, CM Grochowski, KM Loomes, K Bessho… - Human genetics, 2014 - Springer
Abstract In the United States, biliary atresia (BA) is the most frequent indication for liver
transplantation in pediatric patients. BA is a complex disease, with suspected environmental …
transplantation in pediatric patients. BA is a complex disease, with suspected environmental …
[HTML][HTML] Current understanding in the clinical characteristics and molecular mechanisms in different subtypes of biliary atresia
Biliary atresia is a severe obliterative cholangiopathy in early infancy that is by far the most
common cause of surgical jaundice and the most common indicator for liver transplantation …
common cause of surgical jaundice and the most common indicator for liver transplantation …
[HTML][HTML] Loss of a candidate biliary atresia susceptibility gene, add3a, causes biliary developmental defects in zebrafish
V Tang, ZC Cofer, S Cui, V Sapp… - Journal of pediatric …, 2016 - journals.lww.com
Objectives: Biliary atresia (BA) is a progressive fibroinflammatory cholangiopathy affecting
the bile ducts of neonates. Although BA is the leading indication for pediatric liver …
the bile ducts of neonates. Although BA is the leading indication for pediatric liver …
[HTML][HTML] Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes
Background & Aims Biliary atresia (BA) is poorly understood and leads to liver
transplantation (LT), with the requirement for and associated risks of lifelong …
transplantation (LT), with the requirement for and associated risks of lifelong …