Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are
involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose …

Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

Resistance towards chemotherapy, either primary or acquired, represents a major obstacle
in clinical oncology. Three basic categories underlie most cases of chemotherapy failure …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and
resistance to therapy. Responses to hypoxia are orchestrated in part through activation of …