Paracoccidioides brasiliensis and P. lutzii are etiologic agents of paracoccidioidomycosis
(PCM), an important endemic mycosis in Latin America. During its evolution, these fungi …

Innate immunity is based in pre-existing elements of the immune system that directly interact
with all types of microbes leading to their destruction or growth inhibition. Several elements …

Background Paracoccidioides brasiliensis is a human thermal dimorphic pathogenic fungus.
Survival of P. brasiliensis inside the host depends on the adaptation of this fungal pathogen …

Alveolar macrophages (AM) are the first host cells to interact with Paracoccidioides
brasiliensis (Pb), a primary human pathogen that causes severe pulmonary infections in …

Paracoccidioidomycosis is caused by the thermally dimorphic fungus Paracoccidioides
brasiliensis (P. brasiliensis). Most often, this mycosis runs as a chronic progressive course …

Research on Paracoccidioides brasiliensis has centered in the yeast cell probably because
of the lack of distinctive features in the mycelium. In 1942 and for the first time, lateral conidia …

Paracoccidioidomycosis is a deep mycosis, endemic in Latin America, caused by
Paracoccidioides brasiliensis. Macrophage activation by cytokines is the major effector …

Background Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a
dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the …

Infections due to Histoplasma capsulatum occur as a result of the inhalation of airborne
microconidia of the mold into the alveoli of the lungs. In this study we quantified the …

In order to determine the role of lysozyme, an antimicrobial peptide belonging to the innate
immune system, against the dimorphic fungus Paracoccidioides brasiliensis, co-cultures of …