Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

Extracellular vesicles (EVs) play a key role in health and disease, including cancer. Tumors
produce a mix of EVs differing in size, cellular origin, biogenesis and molecular content …

Targeting immune checkpoints has achieved great therapeutic effects in the treatment of
early-stage tumors. However, most patients develop adaptive resistance to this therapy. The …

Interactions between tumor cells and tumor-associated macrophages (TAMs) are critical for
glioblastoma progression. The TAMs represent up to 30% of the glioblastoma mass. The …

Exosome, a subpopulation of extracellular vesicles, plays diverse roles in various biological
processes. As one of the most abundant components of exosomes, exosomal proteins have …

Glioblastoma multiforme (GBM) is the most common primary brain cancer. GBM has
aggressive development, and the pharmacological treatment remains a challenge due to …

The use of cancer-derived exosomes has been studied in several cancer types, but the
cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for …