The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …

Abstract Purpose of Review Suicide is a major public health concern and a leading cause of
death in the US. Alcohol and opioid use disorders (AUD/OUD) significantly increase risk for …

Objectives: Treatment guidelines discourage long-term opioid treatment for patients with
chronic pain and major depression, but this treatment occurs commonly, producing higher …

We recently reported that naltrexone blocks antidepressant effects of ketamine in humans,
indicating that antidepressant effects of ketamine require opioid receptor activation …

Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …

Emotions are states of vigilant readiness that guide human and animal behaviour during
survival‐salient situations. Categorical models of emotions posit neurally and …

The buprenorphine receptor binding profile is unique in that it binds to all three major opioid
receptors (mu, kappa, delta), and also binds to the orphan-like receptor, the receptor for …

Major depressive disorder is associated with lowered mood, anxiety, anhedonia, sleep
problems, and cognitive impairments. Many of these functions are regulated by μ-opioid …