The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
A review of mesoporous silica nanoparticle delivery systems in chemo-based combination cancer therapies
Y Gao, D Gao, J Shen, Q Wang - Frontiers in chemistry, 2020 - frontiersin.org
Chemotherapy is an important anti-tumor treatment in clinic to date, however, the
effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic …
effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic …
One minute analysis of 200 histone posttranslational modifications by direct injection mass spectrometry
DNA and histone proteins define the structure and composition of chromatin. Histone
posttranslational modifications (PTMs) are covalent chemical groups capable of modeling …
posttranslational modifications (PTMs) are covalent chemical groups capable of modeling …
Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells
J Fellenberg, H Sähr, D Mancarella, C Plass… - Cancer letters, 2019 - Elsevier
Giant cell tumors of bone (GCTB) are semi-malignant tumors associated with extensive
osteolytic defects and massive bone destructions. They display a locally aggressive …
osteolytic defects and massive bone destructions. They display a locally aggressive …
Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
K Kawakubo, CF Castillo, AS Liss - Journal of gastroenterology, 2022 - Springer
Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and
immune checkpoint inhibitors. Recent studies suggest that epigenetic alterations contribute …
immune checkpoint inhibitors. Recent studies suggest that epigenetic alterations contribute …
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to
promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this …
promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this …
Leveraging dominant-negative histone H3 K-to-M mutations to study chromatin during differentiation and development
K Serdyukova, AR Swearingen, M Coradin… - …, 2023 - journals.biologists.com
Histone modifications are associated with regulation of gene expression that controls a vast
array of biological processes. Often, these associations are drawn by correlating the …
array of biological processes. Often, these associations are drawn by correlating the …
A Comprehensive Overview of Recent Advances in Epigenetics in Pediatric Acute Lymphoblastic Leukemia
P Drożak, Ł Bryliński, J Zawitkowska - Cancers, 2022 - mdpi.com
Simple Summary Acute lymphoblastic leukemia (ALL) is the most common cancer among
pediatric patients. Thanks to the introduction of revolutionary treatment methods and …
pediatric patients. Thanks to the introduction of revolutionary treatment methods and …
Small interfering RNAs targeting a chromatin-associated RNA induce its transcriptional silencing in human cells
J Ouvrard, L Muniz, E Nicolas… - Molecular and Cellular …, 2022 - Taylor & Francis
Transcriptional gene silencing by small interfering RNAs (siRNAs) has been widely
described in various species, including plants and yeast. In mammals, its extent remains …
described in various species, including plants and yeast. In mammals, its extent remains …
Radiotherapy and radio‐sensitization in H3K27M‐mutated diffuse midline gliomas
Abstract Background H3 K27M mutated diffuse midline gliomas (DMGs) are extremely
aggressive and the leading cause of cancer‐related deaths in pediatric brain tumors with 5 …
aggressive and the leading cause of cancer‐related deaths in pediatric brain tumors with 5 …