Worldwide, smoking remains a threat to public health, causing preventable diseases and
premature mortality. Cigarette smoke is a powerful inducer of DNA methylation and gene …

Women live longer than men but experience greater disability and a longer period of illness
as they age. Despite clear sex differences in aging, the impact of pregnancy and its …

Multiple sclerosis (MS) is an autoimmune, demyelinating disease with the highest incidence
in women of childbearing age. The effect of pregnancy on disease activity and progression …

Background Pregnancy in women with multiple sclerosis (wwMS) is associated with a
reduction of long-term disability progression. The mechanism that drives this effect is …

The process of aging can be defined as the sum accumulation of damages and changes in
metabolism during the life of an organism, due to both genetic predisposition and stochastic …

Given its increasing prevalence, aging is of great concern to researchers worldwide. Cellular
senescence is a physiological or pathological cellular state caused by aging and a …

Regulatory T cells (Tregs) are essential for maternal tolerance in allogeneic pregnancy. In
preeclampsia, Tregs are fewer and display aberrant phenotypes, particularly in the thymic …

Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

During pregnancy and the postpartum, there are dynamic fluctuations in steroid and peptide
hormone levels as well as inflammatory signalling. These changes are required for a healthy …

Addressing these questions could critically impact on the prevention and treatment of
asthma and allergies. Both the original (IOWBC) and the IOW 3rd Gen are based at the …