Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Introduction: Alzheimer's disease (AD) is a world-wide health problem with implications for
an increasing number of people and countries. Populations suffering from AD financially …

Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …

By using fragments endowed with interesting and complementary properties for the
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …

Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …