Translesion DNA synthesis and mutagenesis in eukaryotes
JE Sale - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …
DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
S Boiteux, S Jinks-Robertson - Genetics, 2013 - academic.oup.com
DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …
HLTF promotes fork reversal, limiting replication stress resistance and preventing multiple mechanisms of unrestrained DNA synthesis
DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ
RE Johnson, L Prakash… - Proceedings of the …, 2012 - National Acad Sciences
Replication through a diverse array of DNA lesions occurs by the sequential action of two
translesion synthesis (TLS) DNA polymerases (Pols), in which one inserts the nucleotide …
translesion synthesis (TLS) DNA polymerases (Pols), in which one inserts the nucleotide …
Eukaryotic DNA polymerase ζ
AV Makarova, PM Burgers - DNA repair, 2015 - Elsevier
This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the
bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also …
bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also …
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis
Postreplication repair (PRR) pathways play important roles in restarting stalled replication
forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18 …
forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18 …
DNA damage tolerance: when it's OK to make mistakes
DJ Chang, KA Cimprich - Nature chemical biology, 2009 - nature.com
Mutations can be beneficial under conditions in which genetic diversity is advantageous,
such as somatic hypermutation and antibody generation, but they can also be lethal when …
such as somatic hypermutation and antibody generation, but they can also be lethal when …
Chronological Aging in Saccharomyces cerevisiae
VD Longo, P Fabrizio - Aging Research in Yeast, 2012 - Springer
The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life
span (CLS) and the replicative life span (RLS). The chronological life span is a measure of …
span (CLS) and the replicative life span (RLS). The chronological life span is a measure of …
Functions of ubiquitin and SUMO in DNA replication and replication stress
N García-Rodríguez, RP Wong, HD Ulrich - Frontiers in genetics, 2016 - frontiersin.org
Complete and faithful duplication of its entire genetic material is one of the essential
prerequisites for a proliferating cell to maintain genome stability. Yet, during replication DNA …
prerequisites for a proliferating cell to maintain genome stability. Yet, during replication DNA …
DNA-damage tolerance through PCNA ubiquitination and sumoylation
L Fan, T Bi, L Wang, W Xiao - Biochemical Journal, 2020 - portlandpress.com
DNA-damage tolerance (DDT) is employed by eukaryotic cells to bypass replication-
blocking lesions induced by DNA-damaging agents. In budding yeast Saccharomyces …
blocking lesions induced by DNA-damaging agents. In budding yeast Saccharomyces …