The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Systemic juvenile idiopathic arthritis (SJIA) is a rare disease with distinct features not seen in
other categories of juvenile idiopathic arthritis. In recent years, advances in the …

Purpose: To study the biology and identify markers of severe cytokine release syndrome
(CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) in children after …

Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …

Hemophagocytic lymphohistiocytosis (HLH)–like toxicities are increasingly being
recognized as complications of chimeric antigen receptor (CAR) T-cell therapy. Clinical …

Background People with HIV and mycobacterial infections can develop immune
reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART) …

Background Quantifying T-cell activation is essential for the diagnosis and evaluation of
treatment response in various hyperinflammatory and immune regulatory disorders …

Cytokine storm is an umbrella term that describes an inflammatory syndrome characterized
by elevated levels of circulating cytokines and hyperactivation of innate and/or adaptive …

Background Familial hemophagocytic lymphohistiocytosis is a life-threatening
hyperinflammatory disease caused by genetic defects in the granule-mediated cytotoxic …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome characterized by excessive activation of the immune system, along with …