Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …

Ketamine may have antidepressant properties, but its acute psychoactive effects complicate
successful masking in placebo-controlled trials. Here we present a single-center, parallel …

What is the level of consciousness of the psychedelic state? Empirically, measures of neural
signal diversity such as entropy and Lempel-Ziv (LZ) complexity score higher for wakeful rest …

Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

Background Inadequate pain management after surgery increases the risk of postoperative
complications and may predispose for chronic postsurgical pain. Perioperative ketamine …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Ketamine has been in clinical use for over half a century, yet its precise mechanisms of
action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated …

Introduction: Directional connectivity from anterior to posterior brain regions (or “feedback”
connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the …