Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density
lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and …

Background/Aim A link between an impaired intestinal barrier, endotoxemia, and the
pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been …

In this study, we investigated the effect of diet supplementation with sodium butyrate (5%
w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters …

Pancreatic β-cells, by secreting insulin, play a key role in the control of glucose homeostasis,
and their dysfunction is the basis of diabetes development. The metabolic milieu created by …

We developed a patented jaboticaba peel extract (PJE) aiming to investigate PJE dose-
dependent effect in liver and metabolism of high-fat-fed aging mice. Male FVB mice were …

We recently showed that mTOR attenuation blocks progression and abrogates established
cognitive deficits in Alzheimer's disease (AD) mouse models. These outcomes were …

Metabolic syndrome (MetS) is an increasing global health threat and strong risk factor for
type 2 diabetes (T2D). MetS causes both hyperinsulinemia and islet size overexpansion …

Aims Evidence suggests that administration of a high-fat diet (HFD) results in changes in the
intestinal lumen environment. Gut dysbiosis associated with intestinal barrier disruption may …

The Wnt/β-catenin signaling pathway, also known as the canonical Wnt pathway, plays a
role in cell proliferation and differentiation in several tissues/organs. It has been recently …

Scope A major goal of diabetes therapy is to identify novel drugs that preserve or expand
pancreatic beta cell mass. Here, we examined the effect of a phenylpropenoic acid …