Diabetes and familial hypercholesterolemia: interplay between lipid and glucose metabolism
AM González-Lleó, RM Sánchez-Hernández… - Nutrients, 2022 - mdpi.com
Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density
lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and …
lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase cardiovascular risk and …
High-fat diet induces disruption of the tight junction-mediated paracellular barrier in the proximal small intestine before the onset of type 2 diabetes and endotoxemia
JC Nascimento, VA Matheus, RB Oliveira… - Digestive diseases and …, 2021 - Springer
Background/Aim A link between an impaired intestinal barrier, endotoxemia, and the
pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been …
pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been …
Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice
VA Matheus, LCS Monteiro… - Experimental …, 2017 - journals.sagepub.com
In this study, we investigated the effect of diet supplementation with sodium butyrate (5%
w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters …
w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters …
Cholesterol redistribution in pancreatic β-cells: a flexible path to regulate insulin secretion
Pancreatic β-cells, by secreting insulin, play a key role in the control of glucose homeostasis,
and their dysfunction is the basis of diabetes development. The metabolic milieu created by …
and their dysfunction is the basis of diabetes development. The metabolic milieu created by …
Jaboticaba extract prevents prediabetes and liver steatosis in high-fat-fed aging mice
We developed a patented jaboticaba peel extract (PJE) aiming to investigate PJE dose-
dependent effect in liver and metabolism of high-fat-fed aging mice. Male FVB mice were …
dependent effect in liver and metabolism of high-fat-fed aging mice. Male FVB mice were …
mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment
JB Jahrling, AL Lin, N DeRosa… - Journal of Cerebral …, 2018 - journals.sagepub.com
We recently showed that mTOR attenuation blocks progression and abrogates established
cognitive deficits in Alzheimer's disease (AD) mouse models. These outcomes were …
cognitive deficits in Alzheimer's disease (AD) mouse models. These outcomes were …
Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet
CA Beamish, YK Lee, AO Gaber… - Journal of …, 2024 - joe.bioscientifica.com
Metabolic syndrome (MetS) is an increasing global health threat and strong risk factor for
type 2 diabetes (T2D). MetS causes both hyperinsulinemia and islet size overexpansion …
type 2 diabetes (T2D). MetS causes both hyperinsulinemia and islet size overexpansion …
Intestinal luminal content from high-fat-fed prediabetic mice changes epithelial barrier function in vitro
RB Oliveira, LP Canuto, CB Collares-Buzato - Life sciences, 2019 - Elsevier
Aims Evidence suggests that administration of a high-fat diet (HFD) results in changes in the
intestinal lumen environment. Gut dysbiosis associated with intestinal barrier disruption may …
intestinal lumen environment. Gut dysbiosis associated with intestinal barrier disruption may …
Activation of the Wnt/β-catenin pathway in pancreatic beta cells during the compensatory islet hyperplasia in prediabetic mice
DA Maschio, RB Oliveira, MR Santos… - Biochemical and …, 2016 - Elsevier
The Wnt/β-catenin signaling pathway, also known as the canonical Wnt pathway, plays a
role in cell proliferation and differentiation in several tissues/organs. It has been recently …
role in cell proliferation and differentiation in several tissues/organs. It has been recently …
Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high‐fat diet‐fed mice and protects beta cells from ER stress‐induced apoptosis
I Mathijs, DA Da Cunha, E Himpe… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope A major goal of diabetes therapy is to identify novel drugs that preserve or expand
pancreatic beta cell mass. Here, we examined the effect of a phenylpropenoic acid …
pancreatic beta cell mass. Here, we examined the effect of a phenylpropenoic acid …