Heat shock induced gene expression and other cellular responses help limit the damage
caused by stress and thus facilitate cellular recovery. Cellular damage also triggers …

The vast majority of mammalian testes are located outside the body cavity for proper
thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and …

Heat shock factors (HSFs) are the master regulators of transcription under protein-damaging
conditions, acting in an environment where the overall transcription is silenced. We …

Heat shock factors form a family of transcription factors (four in mammals), which were
named according to the first discovery of their activation by heat shock. As a result of the …

The redox environment of the cell is currently thought to be extremely important to control
cell growth, differentiation, and apoptosis as many redox-sensitive proteins characterize …

Heat shock transcription factors (HSFs), as regulators of heat shock proteins (HSPs)
expression, are well known for their cytoprotective functions during cellular stress. They also …

Highly evolutionary conserved heat shock proteins (HSPs) act as molecular chaperones in
regulation of cellular homeostasis and promoting survival. Generally they are induced by a …

Background The p53 and HSF1 transcription factors are key players in cellular responses to
stress. They activate important signaling pathways triggering adaptive mechanisms that …

The HSPA2 gene is a poorly characterized member of the HSPA (HSP70) family. HSPA2
was originally described as testis-specific and expressed at the highest level in pachytene …

Hypoxia in vivo induces oligozoospermia, azoospermia, and degeneration of the germinal
epithelium, but the underlying molecular mechanism of this induction is not fully clarified …