Neuro-consequences of the spaceflight environment
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …
[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …
has been placed on the cognitive welfare of astronauts, who will likely endure extended …
Cosmic radiation exposure and persistent cognitive dysfunction
VK Parihar, BD Allen, C Caressi, S Kwok, E Chu… - Scientific reports, 2016 - nature.com
The Mars mission will result in an inevitable exposure to cosmic radiation that has been
shown to cause cognitive impairments in rodent models, and possibly in astronauts …
shown to cause cognitive impairments in rodent models, and possibly in astronauts …
Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice
JJ Hinkle, JA Olschowka, TM Love, JP Williams… - Scientific reports, 2019 - nature.com
Cranial irradiation is the main therapeutic treatment for primary and metastatic malignancies
in the brain. However, cranial radiation therapy produces long-term impairment in memory …
in the brain. However, cranial radiation therapy produces long-term impairment in memory …
Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin
J Ma, LQ Zhang, ZX He, XX He, YJ Wang, YL Jian… - PLoS …, 2019 - journals.plos.org
Dendritic spine development is crucial for the establishment of excitatory synaptic
connectivity and functional neural circuits. Alterations in spine morphology and density have …
connectivity and functional neural circuits. Alterations in spine morphology and density have …
Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice
B Liu, RG Hinshaw, KX Le, MA Park, S Wang… - Scientific reports, 2019 - nature.com
Abstract Space travel will expose people to high-energy, heavy particle radiation, and the
cognitive deficits induced by this exposure are not well understood. To investigate the short …
cognitive deficits induced by this exposure are not well understood. To investigate the short …
In the temporal organization of episodic memory, the hippocampus supports the experience of elapsed time
M Sabariego, NS Tabrizi, GJ Marshall… - …, 2021 - Wiley Online Library
Abstract Space and time are both essential features of episodic memory, for which the
hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used …
hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used …
Alterations in synaptic density and myelination in response to exposure to high‐energy charged particles
DL Dickstein, R Talty, E Bresnahan… - Journal of …, 2018 - Wiley Online Library
High‐energy charged particles are considered particularly hazardous components of the
space radiation environment. Such particles include fully ionized energetic nuclei of helium …
space radiation environment. Such particles include fully ionized energetic nuclei of helium …
Cyclic changes and actions of progesterone and allopregnanolone on cognition and hippocampal basal (stratum oriens) dendritic spines of female rats
LM Barreto-Cordero, J Ríos-Carrillo… - Behavioural Brain …, 2020 - Elsevier
Ovarian steroids modulate the neuronal structure and function during the estrous cycle,
contrasting peak effects during the proestrus cycle and low effects during the metestrus …
contrasting peak effects during the proestrus cycle and low effects during the metestrus …
TDP-43 was Involved in Radiation-induced Neuronal Damage and May Not Through the BDNF/TrkB Pathway
R Sun, K Xi, S Ji, X Song, D Xi, W Yin… - Radiation …, 2024 - meridian.allenpress.com
Cognitive dysfunction is the most common form of radiation-induced brain injury. TDP-43 is
known to be associated with hippocampal degeneration and cognitive dysfunction, in this …
known to be associated with hippocampal degeneration and cognitive dysfunction, in this …