Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Pseudomonas aeruginosa is intrinsically resistant to a variety of antimicrobials and can
develop resistance during anti-pseudomonal chemotherapy both of which compromise …

Carbapenems, once considered the last line of defense against of serious infections with
Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem …

Carbapenems are among the most commonly used and the most efficient antibiotics since
they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding …

Background Raman spectroscopy is a powerful technique for the robust, reliable and rapid
detection and discrimination of bacteria. Objectives To develop a rapid and sensitive …

Drug repurposing is a safe and successful pathway to speed up the novel drug discovery
and development processes compared with de novo drug discovery approaches. Drug …

Since the discovery of penicillin 80 years ago, gram‐negative bacteria have become
proficient at evading the lethal activity of β‐lactam antibiotics, principally through the …

The discovery and optimization of a new class of bacterial topoisomerase (DNA gyrase and
topoisomerase IV) inhibitors binding in the ATP domain are described. A fragment molecule …

Antibiotic-resistant Enterobacterales that produce oxacillinase (OXA)-48-like Class D β-
lactamases are often linked to increased clinical mortality. Though the catalytic mechanism …

A series of novel 2-Amino-4-Methylthiazole analogs were developed via three-step reaction
encompassing hydrazine-1-carboximidamide motif to combat Gram-positive and Gram …