Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …

Studies over the past four decades have established that Ca2+ is a critical factor in control of
salivary gland function and have led to identification of the critical components of this …

The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within
endoplasmic reticulum (ER)-plasma membrane (PM) contact sites. Ca2+ signals generated …

The endoplasmic reticulum (ER) is a dynamic structure, playing multiple roles including
calcium storage, protein synthesis and lipid metabolism. During cellular stress, variations in …

The transient receptor potential (TRP) channel superfamily is comprised of a large group of
cation-permeable channels, which display an extraordinary diversity of roles in sensory …

Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely
important role in the maintenance of oral health. Loss of salivary secretion causes a dry …

Transient receptor potential (TRP) channels are polymodal channels capable of sensing
environmental stimuli, which are widely expressed on the plasma membrane of cells and …

The identification of two variants of the canonical pore-forming subunit of the Ca 2+ release-
activated Ca 2+(CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the …