The primary aim of “omic” technologies is the nontargeted identification of all gene products
(transcripts, proteins, and metabolites) present in a specific biological sample. By their …

Metabolomics is the comprehensive study of small molecule metabolites in biological
systems. By assaying and analyzing thousands of metabolites in biological samples, it …

Annotated genome sequences, can be used to reconstruct whole-cell metabolic networks,,,.
These metabolic networks can be modelled and analysed (computed) to study complex …

Recent achievements have been made in the metabolic engineering of plant secondary
metabolism. Various pathways have been altered using genes encoding biosynthetic …

A highly selective and sensitive method for identification and quantification of intracellular
metabolites involved in central carbon metabolism (including glycolysis, pentose phosphate …

Hydrogen is an ideal, clean, and potentially sustainable energy carrier for the future due to
its abundance and non-polluting nature. Numerous bacteria, cyanobacteria, and algae are …

Filamentous fungi have long been used for production of a range of valuable products; with
the advent of molecular biology, it became apparent that these fungi possess considerable …

Various high-throughput experimental techniques are routinely used for generating large
amounts of omics data. In parallel, in silico modelling and simulation approaches are being …

Motivation: Structural studies of metabolic networks yield deeper insight into topology,
functionality and capabilities of the metabolisms of different organisms. Here, we address …

Kinetic information is used to determine the optimal reaction conditions, to successfully scale
up a reaction from the laboratory to the pilot plant, and to improve process control. Obtaining …