Targeting the DNA damage response in immuno-oncology: developments and opportunities
Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …
outcome with regard to multiple tumour types. However, most patients still do not benefit …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer
Abstract Anti-PD-1/PD-L1 agents have transformed the treatment landscape of advanced
non-small cell lung cancer (NSCLC). To expand our understanding of the molecular features …
non-small cell lung cancer (NSCLC). To expand our understanding of the molecular features …
Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple
tumours. However, only a few patients respond to ICIs, which has generated considerable …
tumours. However, only a few patients respond to ICIs, which has generated considerable …
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
L Stolarova, P Kleiblova, M Janatova, J Soukupova… - Cells, 2020 - mdpi.com
Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …
The DNA damage response and inflammation in cancer
Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …
either open or close configuration at specific chromatin locations by orchestrating and …
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction
W Gong, L Lu, Y Zhou, J Liu, H Ma… - American Journal …, 2021 - journals.physiology.org
Stimulator of interferon genes (STING) is an important adaptor in cytosolic DNA-sensing
pathways. A recent study found that the deletion of STING ameliorated cisplatin-induced …
pathways. A recent study found that the deletion of STING ameliorated cisplatin-induced …
Protein degradation: expanding the toolbox to restrain cancer drug resistance
Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …
obstacle. Recent research based on protein degradation to restrain drug resistance has …
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy
ZJ Long, JD Wang, JQ Xu, XX Lei, Q Liu - Molecular Therapy, 2022 - cell.com
The correct duplication and transfer of genetic material to daughter cells is the major event of
cell division. Dysfunction of DNA replication or chromosome segregation presents …
cell division. Dysfunction of DNA replication or chromosome segregation presents …