Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates
a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates …

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been
considered to be relatively 'passive'cells which are responsible for the synthesis and …

Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …

Abstract The Interleukin (IL)-10 cytokine family includes IL-10, IL-19, IL-20, IL-22, IL-24, and
IL-26, which are considered as Class 2α-helical cytokines. IL-10 is the most important …

IL-33 is a newly discovered member of the IL-1 family and has been identified as a potent
inducer of Th2 type immunity. Emerging evidence imply that IL-33 may also act as an alarm …

Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and
can result in amputation and morbidity. Although multiple approaches are used clinically to …

Cytokines are key modulators of inflammatory responses, and play an important role in the
defense and repair mechanisms following trauma. After traumatic injury, an immuno …