Background This is an updated version of the original Cochrane review published in Issue 3,
2006, which included 23 trials. The use of opioids for neuropathic pain remains …

Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …

Background The purpose of this study was to assess whether weaning of opioid use in the
preoperative period improved total joint arthroplasty (TJA) outcomes. Methods Forty-one …

In Australia and New Zealand, in parallel with other developed countries, the number of
patients prescribed opioids on a long-term basis has grown rapidly over the last decade …

Introduction: The use of opioids has been increasing in operating room and intensive care
unit to provide perioperative analgesia as well as stable hemodynamics. However, many …

Objective. Opioids are frequently prescribed for chronic low back pain (CLBP), but there are
broad individual differences in the benefits and risks of opioid therapy, including the …

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia
(OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central …

Objectives: Opioid misuse constitutes a significant public health problem and is associated
with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids …

Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain,
resulting in a steady rise of opioid prescriptions. Subsequently, there has been a striking …

Opinion statement Opioid-induced neurotoxicity (OINT) is a neuropsychiatric syndrome
observed with opioid therapy. The mechanism of OINT is thought to be multifactorial, and …