Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Abstract Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the
peroxiredoxins (PRDXs) family, has multiple functions of glutathione peroxidase (Gpx) …

Neuroimaging and postmortem studies of subjects with major depressive disorder (MDD)
reveal smaller hippocampal volume with lengthening duration of illness. Pathology in …

Suicides are a leading cause of death in psychiatric patients, and in society at large.
Developing more quantitative and objective ways (biomarkers) for predicting and tracking …

There is mounting evidence to suggest aberrant astrocytic function in depression and
suicide. Independent studies have reported astrocytic abnormalities in certain brain regions …

In this study, we investigated the difference in resting-state functional connectivity (RSFC) of
the amygdala between suicide attempters and non-suicide attempters with major depressive …

People that committed suicide were reported to have enhanced levels of gene transcripts for
synaptic proteins in their prefrontal cortex (PFC). Given the close association of suicide with …

Women are under-represented in research on suicidality to date. Although women have a
lower rate of suicide completion than men, due in part to the less-violent methods used, they …

Evidence from epidemiological and laboratory studies, as well as randomized placebo-
controlled trials, suggests supplementation with n-3 polyunsaturated fatty acids (PUFAs) …

Suicide is the 10th leading cause of death in the United States. Although environment has
undeniable impact, evidence suggests that genetic factors play a significant role in …