Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics

K Kurrikoff, B Vunk, Ü Langel - Expert Opinion on Biological …, 2021 - Taylor & Francis
Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …

[HTML][HTML] Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

I Sadeghian, R Heidari, S Sadeghian, MJ Raee… - European Journal of …, 2022 - Elsevier
Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

[HTML][HTML] HPV infections—classification, pathogenesis, and potential new therapies

B Mlynarczyk-Bonikowska, L Rudnicka - International Journal of …, 2024 - mdpi.com
To date, more than 400 types of human papillomavirus (HPV) have been identified. Despite
the creation of effective prophylactic vaccines against the most common genital HPVs, the …

Biological membrane-penetrating peptides: computational prediction and applications

ECL de Oliveira, KS da Costa, PS Taube… - Frontiers in Cellular …, 2022 - frontiersin.org
Peptides comprise a versatile class of biomolecules that present a unique chemical space
with diverse physicochemical and structural properties. Some classes of peptides are able to …

[HTML][HTML] The long and winding road: human papillomavirus entry and subcellular trafficking

MA Ozbun, SK Campos - Current opinion in virology, 2021 - Elsevier
Human papillomaviruses (HPVs) infect and replicate in differentiating mucosal and
cutaneous epithelium. Most HPV infections are asymptomatic or cause transient benign …

Application of cell penetrating peptides as a promising drug carrier to combat viral infections

N Khairkhah, A Namvar, A Bolhassani - Molecular Biotechnology, 2023 - Springer
Novel effective drugs or therapeutic vaccines have been already developed to eradicate
viral infections. Some non-viral carriers have been used for effective drug delivery to a target …

Approaches for the discovery of new cell-penetrating peptides

L Porosk, I Gaidutšik, Ü Langel - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction: The capability of cell-penetrating peptides (CPP), also known as protein
transduction domains (PTD), to enter into cells possibly with an attached cargo, makes their …

Cell-penetrating antimicrobial peptides with anti-infective activity against intracellular pathogens

GS Cruz, AT Santos, EHS Brito, G Radis-Baptista - Antibiotics, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the
intrinsic ability to internalize into a diversity of cell types and simultaneously transport …

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

KE Chen, Q Guo, TA Hill, Y Cui, AK Kendall, Z Yang… - Science …, 2021 - science.org
The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane
trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset …

[HTML][HTML] The emerging roles of retromer and sorting nexins in the life cycle of viruses

Y Lu, P He, Y Zhang, Y Ren, L Zhang - Virologica Sinica, 2022 - Elsevier
Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi
network or plasma membrane. Recent studies have unveiled the emerging roles for retromer …