The administration of an appropriate volume of intravenous fluids, while avoiding fluid
overload, is a major challenge in the pediatric intensive care unit. Despite our efforts, fluid …

Objective: In this Consensus Statement, we review the etiology and pathophysiology of fluid
disturbances in critically ill children with cardiac disease. Clinical tools used to recognize …

Even though hepatic veno-occlusive disease (VOD) is a potentially fatal complication of
hematopoietic cell transplantation (HCT), there is paucity of research on the management of …

Loop diuretics such as furosemide and bumetanide, which act by inhibiting the Na-K-2Cl
cotransporter NKCC2 at the thick ascending limb of the loop of Henle, have been shown to …

Diuretics are among the most commonly prescribed medications for patients with kidney
disease. Most diuretics exert their action by preventing sodium re-absorption from the lumen …

OBJECTIVES The purpose of this study is to describe whether tolerance develops in
pediatric patients receiving chronic intermittent furosemide therapy, to characterize when it …

Objectives: Focusing on critically ill children with cardiac disease, we will review common
causes of fluid perturbations, clinical recognition, and strategies to minimize and treat fluid …

Understanding physiologic water balance and homeostasis mechanisms in the neonate is
critical for clinicians in the NICU as pathologic fluid accumulation increases the risk for …

心肾综合征患者肾功能恶化的主要原因之一不是心输出量下降而是肾静脉高压.
肾静脉高压致急性肾损伤(AKI) 可能与神经, 肌源性, 静脉血容量, 肾素 血管紧张素 …

BackgroundSequential nephron blockade using intravenous chlorothiazide is often used to
enhance urine output in patients with inadequate response to loop diuretics. A few data exist …