Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common
phenotype of corticobasal degeneration) are tauopathies with a relentless course, usually …

Background In the current consensus diagnostic criteria, the diagnosis of probable multiple
system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings …

Clinical diagnosis of multiple system atrophy is challenging and many patients with Lewy
body disease (ie Parkinson's disease or dementia with Lewy bodies) or progressive …

Background Among non-motor symptoms, autonomic disturbances have been described in
amyotrophic lateral sclerosis (ALS) and reported as mild to moderate in up to 75% of …

Background Corneal confocal microscopy (CCM) is a noninvasive, reproducible ophthalmic
technique to quantify corneal small nerve fiber degeneration. CCM demonstrates small …

Background: constipation is one of the most common and disabling non-motor symptoms of
Parkinson Disease (PD) and Parkinsonisms (PS). Few studies evaluate the difference of …

Background The degree of involvement of the autonomic nervous system in progressive
supranuclear palsy (PSP) has been investigated in several studies, often providing …

After decades of research, large-scale clinical trials in patients diagnosed with
frontotemporal lobar degeneration (FTLD) are now underway across multiple centres …

Gastrointestinal (GI) dysfunction is a common nonmotor symptom in Parkinson's disease
(PD) as well as other parkinsonian syndromes and may precede the onset of motor …

Background Rapid development of downgaze palsy, the most specific symptom of
progressive supranuclear palsy (PSP), has been associated with shorter survival in small …