Toward understanding Machado–Joseph disease
M do Carmo Costa, HL Paulson - Progress in neurobiology, 2012 - Elsevier
Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
Expansion of CAG trinucleotide repeat within the coding region of several genes results in
the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of …
the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of …
DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn2 Complex in Human …
M Chauhan, K Banerjee, F Arjmand - Inorganic chemistry, 2007 - ACS Publications
Novel trinuclear complexes C23H31N6O6CuSn2Cl5 [1], C23H31N6O6CuZr2Cl5 [2],
C23H31N6O6ZnSn2Cl5 [3], and C23H31N6O6ZnZr2Cl5 [4] were synthesized and …
C23H31N6O6ZnSn2Cl5 [3], and C23H31N6O6ZnZr2Cl5 [4] were synthesized and …
Machado–Joseph disease/spinocerebellar ataxia type 3
H Paulson - Handbook of clinical neurology, 2012 - Elsevier
Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA3), may be the most common dominantly inherited ataxia in the world. Here I will review …
(SCA3), may be the most common dominantly inherited ataxia in the world. Here I will review …
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado‐Joseph disease
YC Yu, CL Kuo, WL Cheng, CS Liu… - Journal of …, 2009 - Wiley Online Library
Abstract Machado‐Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is an
autosomal dominant neurodegenerative disorder caused by polyglutamine expansion in the …
autosomal dominant neurodegenerative disorder caused by polyglutamine expansion in the …
[HTML][HTML] From pathogenesis to novel therapeutics for spinocerebellar ataxia type 3: evading potholes on the way to translation
Abstract Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …
The role of deubiquitinating enzymes in apoptosis
S Ramakrishna, B Suresh, KH Baek - Cellular and Molecular Life Sciences, 2011 - Springer
It has become apparent that ubiquitination plays a critical role in cell survival and cell death.
In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important …
In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important …
The protective effect of erinacine A–enriched Hericium erinaceus mycelium ethanol extract on oxidative Stress–Induced neurotoxicity in cell and Drosophila models of …
YL Wu, SC Chen, JC Chang, WY Lin, CC Chen… - Free Radical Biology …, 2023 - Elsevier
Spinocerebellar ataxia type 3 (SCA3), or Machado–Joseph disease (MJD), is an inherited
polyglutamine (polyQ) neurodegenerative disease and the most common form of SCA …
polyglutamine (polyQ) neurodegenerative disease and the most common form of SCA …
From pathways to targets: understanding the mechanisms behind polyglutamine disease
JJ Weber, AS Sowa, T Binder… - BioMed research …, 2014 - Wiley Online Library
The history of polyglutamine diseases dates back approximately 20 years to the discovery of
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL
AH Chou, TH Yeh, YL Kuo, YC Kao, MJ Jou… - Neurobiology of …, 2006 - Elsevier
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disease
caused by polyglutamine-expanded ataxin-3. In the present study, we expressed disease …
caused by polyglutamine-expanded ataxin-3. In the present study, we expressed disease …