Electroreductive Cross‐Electrophile Coupling (eXEC) Reactions

Y Liu, P Li, Y Wang, Y Qiu - Angewandte Chemie, 2023 - Wiley Online Library
Electrochemistry utilizes electrons as a potent, controllable, and traceless alternative to
chemical oxidants or reductants, and typically offers a more sustainable option for achieving …

Iron catalysis in organic synthesis: a critical assessment of what it takes to make this base metal a multitasking champion

A Fürstner - ACS Central Science, 2016 - ACS Publications
The current status of homogeneous iron catalysis in organic chemistry is contemplated, as
are the reasons why this particular research area only recently starts challenging the …

Electrochemically enabled, nickel-catalyzed dehydroxylative cross-coupling of alcohols with aryl halides

Z Li, W Sun, X Wang, L Li, Y Zhang… - Journal of the American …, 2021 - ACS Publications
As alcohols are ubiquitous throughout chemical science, this functional group represents a
highly attractive starting material for forging new C–C bonds. Here, we demonstrate that the …

Zinc-free, scalable reductive cross-electrophile coupling driven by electrochemistry in an undivided cell

MC Franke, VR Longley, M Rafiee, SS Stahl… - ACS …, 2022 - ACS Publications
Nickel-catalyzed reductive cross-electrophile coupling reactions are becoming increasingly
important in organic synthesis, but application at scale is limited by three interconnected …

Iron catalysis in organic synthesis

I Bauer, HJ Knölker - Chemical reviews, 2015 - ACS Publications
The present review “Iron Catalysis in Organic Synthesis” covers the literature until the end of
June 2014 and represents a comprehensive update of a previous article published by Bolm …

Reductive cross‐coupling reactions between two electrophiles

CEI Knappke, S Grupe, D Gärtner… - … A European Journal, 2014 - Wiley Online Library
Reductive cross‐electrophile coupling reactions have recently been developed to a versatile
and sustainable synthetic tool for selective C C bond formation. The employment of cheap …

Cross-electrophile coupling: principles of reactivity and selectivity

DA Everson, DJ Weix - The Journal of Organic Chemistry, 2014 - ACS Publications
A critical overview of the catalytic joining of two different electrophiles, cross-electrophile
coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity …

Mechanism and selectivity in nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl halides

S Biswas, DJ Weix - Journal of the American Chemical Society, 2013 - ACS Publications
The direct cross-coupling of two different electrophiles, such as an aryl halide with an alkyl
halide, offers many advantages over conventional cross-coupling methods that require a …

Nickel-catalyzed reductive couplings

X Wang, Y Dai, H Gong - Ni-and Fe-Based Cross-Coupling Reactions, 2017 - Springer
The Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be
an important protocol for the construction of C–C bonds. This chapter first emphasizes the …

Nickel-catalyzed cross-electrophile coupling of aryl chlorides with primary alkyl chlorides

S Kim, MJ Goldfogel, MM Gilbert… - Journal of the American …, 2020 - ACS Publications
Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon
electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross …