The cytosolic calcium concentration ([Ca2+] c) is key for the regulation of many cellular
processes, such cell signaling and proliferation, metabolism, and muscle contraction. In …

Abstract Purpose of Review The purpose of this review is to provide an update on the
current knowledge of the pathophysiology, the mechanisms, and the cardiovascular impact …

Sarcolipin (SLN), a key regulator of cardiac sarco (endo) plasmic reticulum (SR) Ca2+
ATPase, is predominantly expressed in atria and mediates β-adrenergic responses. Studies …

Purpose The antineoplastic anthracycline doxorubicin can induce a dose-dependent
cardiomyopathy that limits the total cumulative dose prescribed to cancer patients. In both …

Background Hypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease,
is the main cause of sudden death in adolescents and athletes globally. Hypoxia and …

Sarcoplasmic reticulum (SR) is a specialized tubular network, which not only maintains the
intracellular concentration of Ca2+ at a low level but is also known to release and …

Heart failure is the leading cause of death in western countries and is often associated with
impaired Ca2+ handling in the cardiomyocyte. In fact, cardiomyocyte relaxation and …

The precise control of Ca2+ levels during the contraction–relaxation cycle in cardiac
myocytes is extremely important for normal beat-to-beat contractile activity. The …

To examine the biological impact of locally expressed stromal cell-derived factor-1α (SDF-
1α) during the acute phase of remodeling after myocardial infarction (MI), rats were treated …

Thyroid hormone (TH) is recognized for its role in cellular metabolism and growth and
participates in homeostasis of the heart. T3 activates pro-survival pathways including Akt …