Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

H Zhang, L Liu, J Liu, P Dang, S Hu, W Yuan, Z Sun… - Molecular Cancer, 2023 - Springer
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

CAR-T cell therapy in hematological malignancies: current opportunities and challenges

X Zhang, L Zhu, H Zhang, S Chen, Y Xiao - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer
treatment, and it has achieved unprecedented success in hematological malignancies …

Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Role of tumor microenvironment in cancer progression and therapeutic strategy

Q Wang, X Shao, Y Zhang, M Zhu, FXC Wang… - Cancer …, 2023 - Wiley Online Library
Cancer is now considered a tumor microenvironment (TME) disease, although it was
originally thought to be a cell and gene expression disorder. Over the past 20 years …

Interferons α and β in cancer: therapeutic opportunities from new insights

EC Borden - Nature Reviews Drug Discovery, 2019 - nature.com
Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

CAR-T cell therapy in multiple myeloma: Current limitations and potential strategies

X Zhang, H Zhang, H Lan, J Wu, Y Xiao - Frontiers in immunology, 2023 - frontiersin.org
Over the last decade, the survival outcome of patients with multiple myeloma (MM) has been
substantially improved with the emergence of novel therapeutic agents, such as proteasome …

Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma

TN Gide, JS Wilmott, RA Scolyer, GV Long - Clinical Cancer Research, 2018 - AACR
Immune checkpoint inhibitors have revolutionized the treatment of patients with advanced-
stage metastatic melanoma, as well as patients with many other solid cancers, yielding long …

Biological characteristics and clinical significance of soluble PD-1/PD-L1 and exosomal PD-L1 in cancer

M Niu, Y Liu, M Yi, D Jiao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
The immune checkpoint pathway consisting of the cell membrane-bound molecule
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …

Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses

Q Chen, M Chen, Z Liu - Chemical Society Reviews, 2019 - pubs.rsc.org
Cancer immunotherapy by educating or stimulating patients' own immune systems to attack
cancer cells has demonstrated promising therapeutic responses in the clinic. However …