Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Invasive candidiasis is an important fungal disease caused by Candida albicans and,
increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most …

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates
with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 …

Highlights•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …