The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
tRNA biology charges to the front
EM Phizicky, AK Hopper - Genes & development, 2010 - genesdev.cshlp.org
tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …
many unexpected discoveries along the way. This review highlights new findings on the …
Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea
M Rother, JA Krzycki - Archaea, 2010 - Wiley Online Library
Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by
their strict dependence on the process of methanogenesis for energy conservation. Among …
their strict dependence on the process of methanogenesis for energy conservation. Among …
Functional context, biosynthesis, and genetic encoding of pyrrolysine
MA Gaston, R Jiang, JA Krzycki - Current opinion in microbiology, 2011 - Elsevier
In Methanosarcina spp., amber codons in methylamine methyltransferase genes are
translated as the 22nd amino acid, pyrrolysine. The responsible pyl genes plus amber …
translated as the 22nd amino acid, pyrrolysine. The responsible pyl genes plus amber …
A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase
The mechanism by which polymerase α–primase (polα–primase) synthesizes chimeric RNA-
DNA primers of defined length and composition, necessary for replication fidelity and …
DNA primers of defined length and composition, necessary for replication fidelity and …
Doing it in reverse: 3′-to-5′ polymerization by the Thg1 superfamily
JE Jackman, JM Gott, MW Gray - Rna, 2012 - rnajournal.cshlp.org
The tRNAHis guanylyltransferase (Thg1) family of enzymes comprises members from all
three domains of life (Eucarya, Bacteria, Archaea). Although the initial activity associated …
three domains of life (Eucarya, Bacteria, Archaea). Although the initial activity associated …
Presence of a classical RRM-fold palm domain in Thg1-type 3'-5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains
Background Almost all known nucleic acid polymerases catalyze 5'-3'polymerization by
mediating the attack on an incoming nucleotide 5'triphosphate by the 3'OH from the growing …
mediating the attack on an incoming nucleotide 5'triphosphate by the 3'OH from the growing …
tRNAHis guanylyltransferase (THG1), a unique 3′-5′ nucleotidyl transferase, shares unexpected structural homology with canonical 5′-3′ DNA polymerases
SJ Hyde, BE Eckenroth, BA Smith… - Proceedings of the …, 2010 - National Acad Sciences
All known DNA and RNA polymerases catalyze the formation of phosphodiester bonds in a
5′ to 3′ direction, suggesting this property is a fundamental feature of maintaining and …
5′ to 3′ direction, suggesting this property is a fundamental feature of maintaining and …
tRNA 5′-end repair activities of tRNA His guanylyltransferase (Thg1)-like proteins from Bacteria and Archaea
BS Rao, EL Maris, JE Jackman - Nucleic acids research, 2011 - academic.oup.com
Abstract The tRNA His guanylyltransferase (Thg1) family comprises a set of unique 3′–5′
nucleotide addition enzymes found ubiquitously in Eukaryotes, where they function in the …
nucleotide addition enzymes found ubiquitously in Eukaryotes, where they function in the …
From end to end: tRNA editing at 5'-and 3'-terminal positions
H Betat, Y Long, JE Jackman, M Mörl - International journal of molecular …, 2014 - mdpi.com
During maturation, tRNA molecules undergo a series of individual processing steps, ranging
from exo-and endonucleolytic trimming reactions at their 5'-and 3'-ends, specific base …
from exo-and endonucleolytic trimming reactions at their 5'-and 3'-ends, specific base …